What are the safety considerations and potential side effects of semaglutide? – Healthcare Select - MWL

Semaglutide is generally well tolerated, but like any medication, it comes with potential side effects. Most are mild and improve over time, while some may require medical attention.

Common Side Effects:

✔️ Nausea, Vomiting, & Upset Stomach – Eating smaller meals and avoiding greasy foods can help. Symptoms often improve as your body adjusts (Mayo Clinic).
✔️ Diarrhea or Constipation – Staying hydrated and increasing fiber intake can help manage digestive changes.
✔️ Loss of Appetite – A reduced desire to eat is common but typically stabilizes over time.

Less Common but Serious Risks:

⚠️ Pancreatitis – Severe abdominal pain, nausea, or vomiting could be signs of inflammation in the pancreas. Seek medical attention if these symptoms occur.
⚠️ Gallbladder Issues – Some patients may experience gallstones or gallbladder inflammation, which can cause pain and nausea.
⚠️ Thyroid Tumor Risk (Rare) – Semaglutide carries a warning for potential thyroid tumors in animal studies. It’s not recommended for those with a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN2) (FDA).

Who Should Avoid Semaglutide?

Individuals with a history of MTC or MEN2
Those with severe gastrointestinal conditions
Patients with a history of pancreatitis should discuss risks with their doctor.

Most side effects improve over time, and staying hydrated, eating balanced meals, and following dosage guidelines can help manage them. If side effects are severe or persistent, consult your healthcare provider to discuss adjustments or alternative options.

Common Side Effects:

Less Common but Serious Risks:

Who Should Avoid Semaglutide?

Further Reading: