Administration:
Orally Dissolving Tablets:
Semaglutide and tirzepatide orally dissolving tablets are mint-flavored and designed to dissolve under your tongue. You should take them in the morning, 30 minutes before eating or drinking anything. This method ensures the medication is absorbed efficiently and starts working effectively. These tablets also contain Pyridoxine HCL (Vitamin B-6) to help reduce nausea and promote overall health.
Injections:
Semaglutide and tirzepatide injections are administered subcutaneously, meaning they are injected under the skin with a needle. Typically, this is done once a week. The injection can be given in the upper arm, thigh, or abdomen.
Convenience:
Orally Dissolving Tablets:
One of the major advantages of orally dissolving tablets is their convenience. They can be taken at home without any special equipment or training, making them a great option for individuals who prefer a simpler and less invasive method of medication administration.
Injections:
While injections can also be administered at home, they require some knowledge of injection techniques. Proper knowledge on how to give the injection safely and effectively is necessary.
Non-invasive:
Orally Dissolving Tablets:
Orally dissolving tablets are non-invasive, meaning they do not involve breaking the skin or causing any discomfort associated with needle injections. This is particularly beneficial for individuals who have a fear of needles or find injections painful or stressful.
Injections:
In contrast, injections are invasive as they involve using a needle to deliver the medication subcutaneously. This can be a barrier for some due to the discomfort or anxiety associated with needles.
Side Effects:
Orally Dissolving Tablets:
The side effects of orally dissolving tablets are similar to those of injections and can include gastrointestinal issues such as nausea, constipation, or diarrhea. It's important to note that the timing of taking orally dissolving tablets in relation to meals can influence these side effects. Following the recommended schedule of taking the tablet 30 minutes before food and drink can help minimize these effects. The inclusion of Pyridoxine HCL (Vitamin B-6) in the tablets also helps to reduce nausea.
Injections:
The side effects of injections also include gastrointestinal issues, and they are generally similar to those of the orally dissolving tablets. However, injections are typically taken without regard to meals, which can be more convenient for some patients.
Conclusion:
Both orally dissolving tablets and injections of semaglutide and tirzepatide have their unique benefits and considerations. Orally dissolving tablets offer a non-invasive and convenient option, ideal for those who prefer not to use needles. On the other hand, injections, while invasive, are straightforward to use after initial usage and do not require specific timing related to meals. Understanding these differences can help you choose the form of GLP-1s that best fits your lifestyle and preferences.
Further Reading:
1. Chubb, Barrie, et al. “Once-Daily Oral Semaglutide versus Injectable GLP-1 RAs in People with Type 2 Diabetes Inadequately Controlled on Basal Insulin: Systematic Review and Network Meta-Analysis.” Diabetes Therapy, 16 Mar. 2021, https://doi.org/10.1007/s13300-021-01034-w.
2. “Taking Semaglutide: Oral Tablets vs. Injections.” Healthline, 5 July 2023, www.healthline.com/health/weight-loss/semaglutide-oral-vs-injection. Accessed 30 Apr. 2024